What are the advantages of organoids compared to other in vitro models?

Organoids can be generated from a wide range of epithelial tissues, including both healthy and diseased intestine, liver, pancreas, breast, and lung, either directly from patient- or animal-derived tissues, or through directed differentiation of pluripotent stem cells. Unlike other patient-derived 3D models, organoids form tissue-like structures that closely recapitulate the histological architecture of the original organ._x000D_ _x000D_ Organoids exhibit long-term expansion capacity without transformation, while maintaining genetic and phenotypic stability and preserving key biological and functional characteristics of the source tissue. The presence of epithelial stem cells supports continuous growth and differentiation into multiple cell types found in the native tissue. In addition, organoid cultures can be scaled and adapted for high-throughput applications, making them a powerful in vitro platform for drug discovery, diagnostics, and patient stratification.