C-013
Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, KRAS (G13D), SMAD4
Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, KRAS (G13D), SMAD4 is a 3D tumor model derived from the sigmoid colon of a colorectal cancer patient, featuring mutations in APC, TP53, KRAS (G13D), and SMAD4. This combination reflects a clinically aggressive colorectal cancer subtype characterized by deregulated Wnt, p53, RAS/MAPK, and TGF-β signaling. The organoid retains the original tumor’s architecture, mutation profile, and cellular heterogeneity. It supports long-term expansion and provides a robust platform for modeling molecular interactions and therapeutic responses in colorectal cancer.
Specifications
- cat no
- C-013
- disease
- Cancer
- organism
- Human
- tissue
- Colon
- growth properties
- Embedded 3D Culture
- biosafety level
- 1
- growth conditions
- 37℃, 95% Air, 5% CO 2
- size quantity
- 1
- product format
- Frozen
- shipping info
- Dry Ice
- storage conditions
- Liquid Nitrogen
- quality control
- All test negative for mycoplasma, bacteria, yeast, and fungi.
- application
- For research use only. Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, KRAS (G13D), SMAD4 is ideal for testing targeted inhibitors against KRAS mutations, as well as combinational strategies involving Wnt and TGF-β pathway modulation. It facilitates studies on tumor heterogeneity, therapy resistance, and biomarker discovery. As a genetically complex model, it enables precision oncology applications and drug development tailored to mutation-specific colorectal cancer. Its in vitro stability makes it a powerful tool for translational research and personalized treatment evaluation.