C-012
Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, SMAD4
Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, SMAD4 is a 3D tumor model cultured from sigmoid colon tissue of a colorectal cancer patient. This organoid harbors key oncogenic mutations in APC, TP53, and SMAD4, representative of advanced colorectal cancer with dysregulated Wnt signaling, impaired DNA damage response, and TGF-β pathway disruption. It preserves the histological structure, genetic integrity, and tumor heterogeneity of the original tissue. The organoid supports sustained in vitro growth, making it ideal for research in site-specific colorectal cancer progression and therapy response.
Specifications
- cat no
- C-012
- disease
- Cancer
- organism
- Human
- tissue
- Colon
- growth properties
- Embedded 3D Culture
- biosafety level
- 1
- growth conditions
- 37℃, 95% Air, 5% CO 2
- size quantity
- 1
- product format
- Frozen
- shipping info
- Dry Ice
- storage conditions
- Liquid Nitrogen
- quality control
- All test negative for mycoplasma, bacteria, yeast, and fungi.
- application
- For research use only. Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, SMAD4 model is highly relevant for investigating targeted therapies against Wnt and TGF-β pathways, understanding the synergy of multiple driver mutations, and validating new treatment combinations. It enables functional assays to evaluate drug resistance, biomarker identification, and tumor evolution. As a representative model of mutation-enriched sigmoid colon cancer, it supports personalized therapy development and translational research into molecularly stratified treatment strategies.