R-007
Recombinant Human R-Spondin 1 (21-146) Protein, Fc Tag
Recombinant Human R-Spondin 1 (21-146) Protein, Fc Tag is a bioactive fragment fused with an Fc domain to enhance stability and potency. R-Spondin 1 amplifies Wnt/β-catenin signaling by binding to LGR receptors and neutralizing RNF43/ZNRF3. It is a core component of organoid media, essential for sustaining intestinal and gastric stem cell populations and enabling long-term epithelial organoid expansion. The Fc tag ensures stability and reproducibility, making it a standard supplement for organoid culture and Wnt pathway research.
Specifications
- cat no
- R-007
- shipping info
- Ice
- application
- For research use only.
- product type
- Growth factor
- product description
- Recombinant Human R-Spondin 1 (21-146) Protein, Fc Tag is a bioactive fragment fused with an Fc domain to enhance stability and potency. R-Spondin 1 amplifies Wnt/β-catenin signaling by binding to LGR receptors and neutralizing RNF43/ZNRF3. It is a core component of organoid media, essential for sustaining intestinal and gastric stem cell populations and enabling long-term epithelial organoid expansion. The Fc tag ensures stability and reproducibility, making it a standard supplement for organoid culture and Wnt pathway research.
- endotoxin level
- Less than 1.0 EU per μg by the LAL method / rFC method.
- sterility
- Negative
- stability and storage
- Store frozen at -20 °C (short-term) or -80°C (long-term)
- molecular weight
- 40.2 kDa
- mycoplasma
- Negative
- purity
- ≥ 95% as determined by SDS-PAGE
- expression system
- Human 293 cells (HEK293)
- formulation
- Lyophilized from 0.22 μm filtered solution in 52 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
- reconstitution
- Please refer to the Certificate of Analysis (CoA) for specific reconstitution instructions.